Tumour Biology

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Retroelement co-option disrupts the cancer transcriptional programme.

Retroelement co-option disrupts the cancer transcriptional programme.

journal contribution posted on 2025-05-09

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer.

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer.

journal contribution posted on 2025-05-06

RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

journal contribution posted on 2025-04-29

Drosophila AHR limits tumor growth and stem cell proliferation in the intestine

Drosophila AHR limits tumor growth and stem cell proliferation in the intestine

journal contribution posted on 2025-04-28

NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants

NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants

journal contribution posted on 2025-04-16

Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction.

Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction.

journal contribution posted on 2025-04-16

The role of extracellular matrix viscoelasticity in development and disease.

The role of extracellular matrix viscoelasticity in development and disease.

journal contribution posted on 2025-04-14

A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines.

A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines.

journal contribution posted on 2025-04-10

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures.

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures.

journal contribution posted on 2025-04-09

Intrinsic electrical activity drives small-cell lung cancer progression.

Intrinsic electrical activity drives small-cell lung cancer progression.

journal contribution posted on 2025-04-09

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics.

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics.

journal contribution posted on 2025-04-07

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis.

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis.

journal contribution posted on 2025-04-07

Imperfect wound healing sets the stage for chronic diseases.

Imperfect wound healing sets the stage for chronic diseases.

journal contribution posted on 2025-03-31

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.

journal contribution posted on 2025-03-27

Becker naevi are associated with neurologic abnormalities.

Becker naevi are associated with neurologic abnormalities.

journal contribution posted on 2025-03-19

Evolving our understanding of cancer: an interview with Charles Swanton.

Evolving our understanding of cancer: an interview with Charles Swanton.

journal contribution posted on 2025-03-17

Charles Swanton

Tracking nongenetic evolution from primary to metastatic ccRCC: TRACERx Renal.

Tracking nongenetic evolution from primary to metastatic ccRCC: TRACERx Renal.

journal contribution posted on 2025-03-06

Targeting the PREX2/RAC1/PI3Kβ signaling axis confers sensitivity to clinically relevant therapeutic approaches in melanoma.

Targeting the PREX2/RAC1/PI3Kβ signaling axis confers sensitivity to clinically relevant therapeutic approaches in melanoma.

journal contribution posted on 2025-02-21

Uncertainty of risk estimates from clinical prediction models: rationale, challenges, and approaches

Uncertainty of risk estimates from clinical prediction models: rationale, challenges, and approaches

journal contribution posted on 2025-02-18

Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis.

Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis.

journal contribution posted on 2025-02-18

Data associated with "A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics"

Data associated with "A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics"

figure posted on 2025-02-12

A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer

A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer

journal contribution posted on 2025-02-12

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer.

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer.

journal contribution posted on 2025-02-06

Oncogenic PIK3CA corrupts growth factor signaling specificity.

Oncogenic PIK3CA corrupts growth factor signaling specificity.

journal contribution posted on 2025-02-06

Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.

Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.

journal contribution posted on 2025-01-30

Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.

Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.

journal contribution posted on 2025-01-24

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.

journal contribution posted on 2025-01-16

Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER

Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER

journal contribution posted on 2025-01-16

Chemical glycobiology.

Chemical glycobiology.

journal contribution posted on 2025-01-13

Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study.

Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study.

journal contribution posted on 2025-01-07

JOURNAL CONTRIBUTION

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis.

journal contribution posted on 2025-01-06

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography.

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography.

journal contribution posted on 2025-01-02

RNA therapy for oncogenic NRAS-driven naevi induces apoptosis.

RNA therapy for oncogenic NRAS-driven naevi induces apoptosis.

journal contribution posted on 2024-12-12

Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment.

Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment.

journal contribution posted on 2024-12-09

Biofabrication and biomanufacturing in Ireland and the UK

Biofabrication and biomanufacturing in Ireland and the UK

journal contribution posted on 2024-12-05

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer.

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer.

journal contribution posted on 2024-12-05

IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells.

IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells.

journal contribution posted on 2024-11-26

A modular protein language modelling approach to immunogenicity prediction.

A modular protein language modelling approach to immunogenicity prediction.

journal contribution posted on 2024-11-22

Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign

Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign

journal contribution posted on 2024-11-19

MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.

MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.

journal contribution posted on 2024-11-07