Analysis of intratumor heterogeneity unravels lung cancer evolution

© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Elza C de Bruin, Nicholas McGranahan, and Charles Swanton. Lung cancer is a disease with dismal outcome. We recently reported a detailed intratumor heterogeneity analysis in 7 non-small cell lung cancer samples, revealing spatially separated driver events as well as the temporal dynamics of mutational processes and demonstrating an important role for APOBEC-mediated heterogeneity later in disease evolution.