Structural Biology & Biophysics

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CARM1/PRMT4 facilitates XPF-ERCC1 heterodimer assembly and maintains nucleotide excision repair activity.

CARM1/PRMT4 facilitates XPF-ERCC1 heterodimer assembly and maintains nucleotide excision repair activity.

journal contribution posted on 2025-05-06

How similar are the molecular mechanisms of yeast and metazoan genome replication initiation?

How similar are the molecular mechanisms of yeast and metazoan genome replication initiation?

journal contribution posted on 2025-05-02

The bat influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment.

The bat influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment.

journal contribution posted on 2025-04-28

Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling.

Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling.

journal contribution posted on 2025-04-28

Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multisite polarity substrate Lgl.

Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multisite polarity substrate Lgl.

journal contribution posted on 2025-04-16

A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression

A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression

journal contribution posted on 2025-04-15

Identification of RING E3 pseudoligases in the TRIM protein family.

Identification of RING E3 pseudoligases in the TRIM protein family.

journal contribution posted on 2025-04-14

The role of extracellular matrix viscoelasticity in development and disease.

The role of extracellular matrix viscoelasticity in development and disease.

journal contribution posted on 2025-04-14

Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production.

Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production.

journal contribution posted on 2025-04-10

Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN.

Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN.

journal contribution posted on 2025-04-09

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics.

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics.

journal contribution posted on 2025-04-07

A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation.

A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation.

journal contribution posted on 2025-03-24

Structural plasticity of Plasmodium falciparum plasmepsin X to accommodate binding of potent macrocyclic hydroxyethylamine inhibitors.

Structural plasticity of Plasmodium falciparum plasmepsin X to accommodate binding of potent macrocyclic hydroxyethylamine inhibitors.

journal contribution posted on 2025-03-19

Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes

Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes

journal contribution posted on 2025-03-19

A scaleable inducible knockout system for studying essential gene function in the malaria parasite.

A scaleable inducible knockout system for studying essential gene function in the malaria parasite.

journal contribution posted on 2025-03-06

Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling

Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling

journal contribution posted on 2025-02-27

Semisynthesis of isomerized histone H4 reveals robustness and vulnerability of chromatin toward molecular aging.

Semisynthesis of isomerized histone H4 reveals robustness and vulnerability of chromatin toward molecular aging.

journal contribution posted on 2025-02-12

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin

journal contribution posted on 2025-02-12

Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets.

Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets.

journal contribution posted on 2025-01-21

Unidirectional MCM translocation away from ORC drives origin licensing.

Unidirectional MCM translocation away from ORC drives origin licensing.

journal contribution posted on 2025-01-20

Life and death of Yfh1: how cool is cold denaturation.

Life and death of Yfh1: how cool is cold denaturation.

journal contribution posted on 2025-01-20

Micromolar fluoride contamination arising from glass NMR tubes and a simple solution for biomolecular applications.

Micromolar fluoride contamination arising from glass NMR tubes and a simple solution for biomolecular applications.

journal contribution posted on 2025-01-15

Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study.

Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study.

journal contribution posted on 2025-01-07

Resolving chaperone-assisted protein folding on the ribosome at the peptide level.

Resolving chaperone-assisted protein folding on the ribosome at the peptide level.

journal contribution posted on 2024-12-13

MCM double hexamer loading visualized with human proteins.

MCM double hexamer loading visualized with human proteins.

journal contribution posted on 2024-12-12

Space synthetic biology: A paradigm for sustainability on earth and beyond

Space synthetic biology: A paradigm for sustainability on earth and beyond

journal contribution posted on 2024-12-12

Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign

Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign

journal contribution posted on 2024-11-19

Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size.

Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size.

journal contribution posted on 2024-11-15

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation.

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation.

journal contribution posted on 2024-11-15

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.

journal contribution posted on 2024-11-14

Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork.

Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork.

journal contribution posted on 2024-11-14

A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.

A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.

journal contribution posted on 2024-11-14

MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.

MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.

journal contribution posted on 2024-11-07

Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M.

Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M.

journal contribution posted on 2024-11-04

Morphogens in the evolution of size, shape and patterning.

Morphogens in the evolution of size, shape and patterning.

journal contribution posted on 2024-10-24

HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA.

HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA.

journal contribution posted on 2024-10-21

A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation.

A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation.

journal contribution posted on 2024-10-17

Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity.

Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity.

journal contribution posted on 2024-10-16

Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium falciparum merozoite-erythrocyte attachment

Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium falciparum merozoite-erythrocyte attachment

journal contribution posted on 2024-10-10

Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole.

Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole.

journal contribution posted on 2024-10-08