PrEP programmes as a framework for tackling HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa

Sukali, Gloria; Okesola, Nonhlanhla; Herbst, Carina; Dreyer, Jaco; Busang, Jacob; Anderson, Motswedi; Iwuji, Collins; Delphin, Marion; Upton, Janine-Lee; Matthews, Philippa; Shahmanesh, Maryam

doi:10.25418/crick.28902671.v1

PrEP programmes as a framework for tackling HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa

presentation

posted on 2025-05-06, 13:29 authored by Gloria SukaliGloria Sukali, Nonhlanhla Okesola, Carina Herbst, Jaco Dreyer, Jacob Busang, Motswedi Anderson, Collins Iwuji, Marion DelphinMarion Delphin, Janine-Lee Upton, Philippa MatthewsPhilippa Matthews, Maryam Shahmanesh

These materials have been presented at the Global Hepatitis Summit (GHS) 2025 in Los Angeles, to support the new Evaluation of Vukuzazi LiVEr disease - Hepatitis B 'EVOLVE-HBV' study based at the Africa Health Research Institute (AHRI) in KwaZulu Natal, South Africa.

‘EVOLVE-HBV’ research programme explored the PrEP uptake and retention cascade amongst adolescents and youth aged 15-30-year-olds and living with HBV through decentralized sexual health /HIV services of the ‘Thetha nami ngithethe nawe’ and the Long-acting HIV Pre-Exposure Prophylaxis (LAPIS) study.

Specific Aim

Aim: We set out to use data from PrEP studies to determine results of HBV screening, treatment uptake and retention amongst adolescents and young adults aged 15-30 years.

Ethics and governance

This work has been approved under the terms of the EVOLVE-HBV project ethics: University of KwaZulu Natal (UKZN) Biomedical Research Ethics Committee (BREC, ref. 00004495/2022) and University College London, UK ethics committee (ref. 23221/001 EVOLVE-HBV).

PrEP HIV studies: (BREC/00000473/2019 and BREC/00003735/2021).