Chemoresistance in triple negative breast cancer, by imaging-guided MS-proteomics

Poster presented as part of the Crick BioImage Analysis Symposium 2023.

Context

• Cancer patients suffer from treatment resistance
• Current proteomic approaches lose spatial or cell type resolution
• Unclear driving factors in TME for treatment outcome

Goal

• Understand cancer treatment response by profiling the tumor microenvironment with spatial and cell-type resolved proteomics

So far

• Established open-source image analysis pipeline
• Imaging of 88 patients, before and after treatment, 4 cores each
• Quantifying up to ~4500 protein per cell-type

Permission has been given by authors to upload to Crick Figshare. Copyright remains with the original authors.