γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis.
journal contributionposted on 2020-10-23, 11:58 authored by L Monin, DS Ushakov, H Arnesen, N Bah, A Jandke, M Muñoz-Ruiz, J Carvalho, S Joseph, BC Almeida, MJ Green, E Nye, S Hatano, Y Yoshikai, M Curtis, H Carlsen, U Steinhoff, P Boysen, A Hayday
This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compose a unique local T-cell compartment. Consistent with earlier reports, most cells expressed a canonical Vγ6Vδ1 TCR, and produced interleukin (IL)-17A upon stimulation. Nonetheless, contrasting with earlier reports, uterine γδ T cells were not obviously intraepithelial, being more akin to sub-epithelial Vγ6Vδ1+ T cells at several other anatomical sites. By contrast to other tissues however, the uterine compartment also included non-Vγ6+, IFN-γ-producing cells; was strikingly enriched in young mice; expressed genes hitherto associated with the uterus, including the progesterone receptor; and did not require microbes for development and/or maintenance. This notwithstanding, γδ T-cell deficiency severely impaired resistance to reproductive tract infection by Candida albicans, associated with decreased responses of IL-17-dependent neutrophils. These findings emphasise tissue-specific complexities of different mucosal γδ cell compartments, and their evident importance in lymphoid stress-surveillance against barrier infection.