White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies
journal contributionposted on 2021-08-18, 11:48 authored by Alan J Burns, Allan M Goldstein, Donald F Newgreen, Lincon Stamp, Karl-Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M Young, Peter W Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D Gershon, Robert O Heuckeroth, Robert MW Hofstra, Lothar Just, Raj P Kapur, Sebastian K King, Conor J McCann, Nandor Nagy, Elly Ngan, Florian Obermayr, Vassilis Pachnis, Pankaj J Pasricha, Mai Har Sham, Paul Tam, Pieter Vanden Berghe
Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.
Cell replacement therapyEnteric nervous systemEnteric neuropathiesHirschsprung diseaseStem cellsAnimalsCell- and Tissue-Based TherapyDisease Models, AnimalEnteric Nervous SystemGastrointestinal TractGuidelines as TopicHirschsprung DiseaseHumansIntestinal Pseudo-ObstructionNeural Stem CellsStem Cell TransplantationPachnis FC001128Developmental Biology06 Biological Sciences11 Medical and Health Sciences