The Francis Crick Institute
Cantwell-Nurse2019_Article_UnravellingNuclearSizeControl.pdf (578.7 kB)

Unravelling nuclear size control.

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journal contribution
posted on 2020-10-27, 12:26 authored by Helena Cantwell, Paul Nurse
Correlation between nuclear and cell size, the nucleocytoplasmic ratio, is a cellular phenomenon that has been reported throughout eukaryotes for more than a century but the mechanisms that achieve it are not well understood. Here, we review work that has shed light on the cellular processes involved in nuclear size control. These studies have implicated nucleocytoplasmic transport, LINC complexes, RNA processing, regulation of nuclear envelope expansion and partitioning of importin α in nuclear size control, moving us closer to a mechanistic understanding of this phenomenon.


Crick (Grant ID: 10121, Grant title: Nurse FC001121) Wellcome Trust (Grant ID: 093917/C/10/A, Grant title: WT 093917/C/10/A)