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Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism

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journal contribution
posted on 14.12.2021, 10:41 by Rachel PJ Lai, Teresa Cortes, Suzaan Marais, Neesha Rockwood, Melissa L Burke, Acely Garza-Garcia, Stuart Horswell, Abdul K Sesay, Anne O’Garra, Douglas B Young, Robert J Wilkinson
Although a few studies have described the microbiome composition of TB sputa based on 16S ribosomal DNA, these studies did not compare to non-TB samples and the nature of the method does not allow any functional inference. This is the first study to apply such technology using clinical specimens and obtained functional transcriptional data on all three aspects simultaneously.

Funding

Crick (Grant ID: 10126, Grant title: O' Garra FC001126) Crick (Grant ID: 10222, Grant title: Young FC001222) Crick (Grant ID: 10218, Grant title: Wilkinson, R FC001218) Crick (Grant ID: 10002, Grant title: STP Bioinformatics & Biostatistics) Crick (Grant ID: 10001, Grant title: STP Advanced Sequencing) Crick (Grant ID: 10060, Grant title: Carvalho FC001060)

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