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The interferon landscape along the respiratory tract impacts the severity of COVID-19.

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journal contribution
posted on 2021-09-27, 11:05 authored by Benedetta Sposito, Achille Broggi, Laura Pandolfi, Stefania Crotta, Nicola Clementi, Roberto Ferrarese, Sofia Sisti, Elena Criscuolo, Roberto Spreafico, Jaclyn M Long, Alessandro Ambrosi, Enju Liu, Vanessa Frangipane, Laura Saracino, Sara Bozzini, Laura Marongiu, Fabio A Facchini, Andrea Bottazzi, Tommaso Fossali, Riccardo Colombo, Massimo Clementi, Elena Tagliabue, Janet Chou, Antonio E Pontiroli, Federica Meloni, Andreas Wack, Nicasio Mancini, Ivan Zanoni
Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found that high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high viral burden but reduced disease risk or severity. Production of specific IFN-III, but not IFN-I, members denotes patients with a mild pathology and efficiently drives the transcription of genes that protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast, compared to subjects with other infectious or noninfectious lung pathologies, IFNs are overrepresented in the lower airways of patients with severe COVID-19 that exhibit gene pathways associated with increased apoptosis and decreased proliferation. Our data demonstrate a dynamic production of IFNs in SARS-CoV-2-infected patients and show IFNs play opposing roles at distinct anatomical sites.


Crick (Grant ID: 10206, Grant title: Wack FC001206)