The Francis Crick Institute
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The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

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journal contribution
posted on 2020-10-19, 14:39 authored by Gareth Prosser, Brandenburg Julius, Norbert Reiling, Clifton Earl Barry, Robert J Wilkinson, Katalin A Wilkinson
Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines.