Synthesis and photolytic assessment of nitroindolinyl-caged calcium ion chelators
journal contributionposted on 2022-05-13, 10:30 authored by George Papageorgiou, John ET Corrie
Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.