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Synthesis and photolytic assessment of nitroindolinyl-caged calcium ion chelators

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journal contribution
posted on 13.05.2022, 10:30 authored by George Papageorgiou, John ET Corrie
Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.

Funding

Crick (Grant ID: 10013, Grant title: STP Peptide Chemistry)

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