jcb_201801104.pdf (660.39 kB)

SNAREing an ARP requires a LIR

Download (660.39 kB)
journal contribution
posted on 17.08.2021, 11:06 by Sharon A Tooze
The fusion of autophagosomes with lysosomes is an obligatory step in the self-eating process of autophagy. In this issue, Kumar et al. (2018. J. Cell Biol. identify a protein complex, the autophagosome recognition particle (ARP), that chaperones a key SNARE, syntaxin 17, to the autophagosome membrane. Intriguingly, this protein complex coordinates both delivery and membrane insertion as a prelude to fusion.