Role of the microenvironment in myeloid malignancies
journal contributionposted on 17.08.2021, 10:49 authored by Marie Goulard, Christine Dosquet, Dominique Bonnet
The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment.
Bone marrow nicheLeukemic-initiating cellsMesenchymal stroma cellsMyeloid malignanciesAnimalsCellular MicroenvironmentHematopoietic Stem CellsHomeostasisHumansMyeloid CellsNeoplasmsNeoplastic Stem CellsStem Cell NicheBonnet FC001045Biochemistry & Molecular Biology0601 Biochemistry and Cell Biology0606 Physiology1103 Clinical Sciences