The Francis Crick Institute
Goulard2018_Article_RoleOfTheMicroenvironmentInMye.pdf (1.24 MB)

Role of the microenvironment in myeloid malignancies

Download (1.24 MB)
journal contribution
posted on 2021-08-17, 10:49 authored by Marie Goulard, Christine Dosquet, Dominique Bonnet
The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment.