Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone.

Stek, Cari; Shey, Muki; Mnika, Khuthala; Schutz, Charlotte; Thienemann, Friedrich; Wilkinson, Robert J; Lynen, Lutgarde; Meintjes, Graeme

doi:10.25418/crick.23898645.v1

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Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone.

journal contribution

posted on 2023-08-07, 08:34 authored by Cari Stek, Muki Shey, Khuthala Mnika, Charlotte Schutz, Friedrich Thienemann, Robert J Wilkinson, Lutgarde Lynen, Graeme Meintjes

The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.