The Francis Crick Institute
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Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

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journal contribution
posted on 2021-05-19, 11:26 authored by Leona Gabryšová, Anne O'Garra
In this issue of JEM, two complementary manuscripts by Huynh et al. ( and Yu et al. ( demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with Mycobacterium tuberculosis or Toxoplasma gondii. Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production.