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Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains.

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journal contribution
posted on 10.08.2021, 09:35 by Nikhil Faulkner, Kevin W Ng, Mary Y Wu, Ruth Harvey, Marios Margaritis, Stavroula Paraskevopoulou, Catherine Houlihan, Saira Hussain, Maria Greco, William Bolland, Scott Warchal, Judith Heaney, Hannah Rickman, Moria Spyer, Daniel Frampton, Matthew Byott, Tulio de Oliveira, Alex Sigal, Svend Kjaer, Charles Swanton, Sonia Gandhi, Rupert Beale, Steve J Gamblin, John W McCauley, Rodney Stuart Daniels, Michael Howell, David Bauer, Eleni Nastouli, SAFER Investigators, George Kassiotis
Background: The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood. Methods: We examined the immunogenicity of SARS-CoV-2 variant B.1.1.7 (Alpha) that arose in the United Kingdom and spread globally. We determined titres of spike glycoprotein-binding antibodies and authentic virus neutralising antibodies induced by B.1.1.7 infection to infer homotypic and heterotypic immunity. Results: Antibodies elicited by B.1.1.7 infection exhibited significantly reduced recognition and neutralisation of parental strains or of the South Africa variant B.1.351 (Beta) than of the infecting variant. The drop in cross-reactivity was significantly more pronounced following B.1.1.7 than parental strain infection. Conclusions: The results indicate that heterotypic immunity induced by SARS-CoV-2 variants is asymmetric.

Funding

Crick (Grant ID: 10169, Grant title: Swanton FC001169) Crick (Grant ID: 11104, Grant title: Bauer FC011104) Crick (Grant ID: 10827, Grant title: Beale FC001827) Crick (Grant ID: 10008, Grant title: STP High Throughput Screening) Crick (Grant ID: 10099, Grant title: Kassiotis FC001099) Crick (Grant ID: 10030, Grant title: McCauley FC001030) Crick (Grant ID: 10078, Grant title: Gamblin FC001078) Crick (Grant ID: 10015, Grant title: STP Structural Biology)

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