The Francis Crick Institute
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Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action.

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journal contribution
posted on 2023-07-24, 11:31 authored by Jessica E Waters, Lars Stevens-Cullinane, Lukas Siebenmann, Jeannine Hess
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning threats to public health worldwide. With low economic incentives and a dwindling supply of new drugs in clinical pipelines, more innovative approaches to novel drug design and development are desperately required. Metal-based compounds are rapidly emerging as an alternative to organic drugs, as they have the ability to kill pathogens via metal-specific modes of action. We herein review recent advances in metal-based antibacterial agents, including metal complexes, metal ions and catalytic metallodrugs. The review concludes with a perspective on the rational design of metal-based antibiotics, and how we can exploit their unique properties to tackle AMR.


Crick (Grant ID: CC2215, Grant title: Hess CC2215)