Rab GTPases in immunity and inflammation
journal contributionposted on 17.08.2021, 12:31 authored by A Prashar, L Schnettger, EM Bernard, MG Gutierrez
Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master regulators of membrane trafficking. In this review, we discuss the cellular and molecular mechanisms by which Rab GTPases regulate immunity and inflammation.
Rab GTPaseinflammationinnate immunitymacrophagesphagosomesAdaptive ImmunityAnimalsAutophagyExocytosisHomeostasisHumansImmune System DiseasesImmunityImmunity, InnateInflammationMacrophagesPhagosomesProtein TransportSecretory Vesiclesrab GTP-Binding ProteinsGutierrez FC0010920601 Biochemistry and Cell Biology0605 Microbiology