Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia.

Jatho, Aline; Zieseniss, Anke; Brechtel-Curth, Katja; Yamamoto, Atsushi; Coleman, Mathew L; Leon, Ana M Vergel; Biggs, Daniel; Davies, Ben; Pugh, Chris W; Ratcliffe, Peter J; Katschinski, Dörthe M

Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia.

journal contribution

posted on 2021-04-27, 08:52 authored by Aline Jatho, Anke Zieseniss, Katja Brechtel-Curth, Atsushi Yamamoto, Mathew L Coleman, Ana M Vergel Leon, Daniel Biggs, Ben Davies, Chris W Pugh, Peter J Ratcliffe, Dörthe M Katschinski

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Crick (Grant ID: 10501, Grant title: Ratcliffe FC001501)

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https://doi.org/10.1161/CIRCRESAHA.120.318216

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Keywords

Prolyl Hydroxylase domain enzyme doxycycline heart failure incidence myocardial infarction prolyl hydroxylase Ratcliffe FC001501 1102 Cardiorespiratory Medicine and Haematology 1103 Clinical Sciences Cardiovascular System & Hematology

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CC BY 4.0

Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia.

Funding

Crick (Grant ID: 10501, Grant title: Ratcliffe FC001501)

History

Publisher DOI

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