The Francis Crick Institute
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Positive selection in the light zone of germinal centers.

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journal contribution
posted on 2021-04-30, 09:47 authored by Rinako Nakagawa, Dinis Pedro Calado
Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination. Affinity maturation and permissive selection in GCs are key for the production of PCs and MBCs, respectively. For these purposes, GCs positively select "fit" cells in the light zone of the GC and instructs them for one of three known B cell fates: PCs, MBCs and persistent GC-B cells as dark zone entrants. In this review, we provide an overview of the positive selection process and discuss its mechanisms and how B cell fates are instructed.


Crick (Grant ID: 10057, Grant title: Calado FC001057) Medical Research Council (Grant ID: MR/J008060/1, Grant title: MRC MR/J008060/1)