The Francis Crick Institute
hernandez-gonzalez-et-al-2024-palisade-structure-in-intact-vaccinia-virions (3).pdf (5 MB)

Palisade structure in intact vaccinia virions.

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journal contribution
posted on 2024-02-22, 12:19 authored by Miguel Hernandez-Gonzalez, Thomas Calcraft, Andrea Nans, Peter B Rosenthal, Michael Way
Poxviruses such as variola virus (smallpox) and monkeypox cause diseases in humans. Other poxviruses, including vaccinia and modified vaccinia Ankara, are used as vaccine vectors. Given their importance, a greater structural understanding of poxvirus virions is needed. We now performed cryo-electron tomography of purified intact vaccinia virions to study the structure of the palisade, a protein lattice that defines the viral core boundary. We identified the main viral proteins that form the palisade and their interaction surfaces and provided new insights into the organization of the viral core.


Crick (Grant ID: CC2096, Grant title: Way CC2096) Crick (Grant ID: CC2106, Grant title: Rosenthal CC2106) Crick (Grant ID: CC1068, Grant title: STP Structural Biology)