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Mutant p53 in cell-cell interactions

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journal contribution
posted on 21.04.2021, 08:51 by Steven Pilley, Tristan A Rodriguez, Karen H Vousden
p53 is an important tumor suppressor, and the complexities of p53 function in regulating cancer cell behaviour are well established. Many cancers lose or express mutant forms of p53, with evidence that the type of alteration affecting p53 may differentially impact cancer development and progression. It is also clear that in addition to cell-autonomous functions, p53 status also affects the way cancer cells interact with each other. In this review, we briefly examine the impact of different p53 mutations and focus on how heterogeneity of p53 status can affect relationships between cells within a tumor.

Funding

Crick (Grant ID: 10557, Grant title: Vousden FC001557) Cancer Research UK (Grant ID: 26855, Grant title: CRUK C596/A26855)

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