The Francis Crick Institute
s12915-017-0432-0.pdf (3.58 MB)

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers

Download (3.58 MB)
journal contribution
posted on 2021-08-17, 11:38 authored by Christopher J Stefan, William S Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M Valm, Jennifer Lippincott-Schwartz, Tim P Levine, David B Iaea, Frederick R Maxfield, Clare E Futter, Emily R Eden, Delphine Judith, Alexander R van Vliet, Patrizia Agostinis, Sharon A Tooze, Ayumu Sugiura, Heidi M McBride
Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.