The Francis Crick Institute
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Mechanistic diversity in MHC class I antigen recognition.

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journal contribution
posted on 2022-01-10, 14:24 authored by Camila RR Barbosa, Justin Barton, Adrian J Shepherd, Michele Mishto
Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8+ T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial: the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8+ T cells.