MST kinases in development and disease
journal contributionposted on 19.08.2021, 10:30 by Barry J Thompson, Erik Sahai
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1). MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cancer, endothelial malformations, and autoimmune disease.
AnimalsAutoimmune DiseasesCell MovementCell PolarityCell ProliferationEmbryonic DevelopmentEndothelium, VascularFungal ProteinsGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHumansNeoplasmsOrgan SizeProtein-Serine-Threonine KinasesSignal TransductionSubstrate SpecificitySahaiThompson06 Biological Sciences11 Medical and Health SciencesDevelopmental Biology