The Francis Crick Institute
bcj-2023-0390.pdf (1.85 MB)

Into the fold: advances in understanding aPKC membrane dynamics.

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journal contribution
posted on 2024-01-03, 10:25 authored by Mathias Cobbaut, Peter J Parker, Neil Q McDonald
Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don't respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+. They are central to the organization of polarized cells and are deregulated in several cancers. aPKC recruitment to the plasma membrane compartment is crucial to their encounter with substrates associated with polarizing functions. However, in contrast with other PKCs, the mechanism by which atypical PKCs are recruited there has remained elusive until recently. Here, we bring aPKC into the fold, summarizing recent reports on the direct recruitment of aPKC to membranes, providing insight into seemingly discrepant findings and integrating them with existing literature.


Crick (Grant ID: CC2068, Grant title: McDonald CC2068) Crick (Grant ID: CC2140, Grant title: Parker CC2140)