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Inhibitory control of prefrontal cortex by the claustrum
journal contributionposted on 2020-08-12, 13:33 authored by Jesse Jackson, Mahesh M Karnani, Boris V Zemelman, Denis Burdakov, Albert K Lee
The claustrum is a small subcortical nucleus that has extensive excitatory connections with many cortical areas. While the anatomical connectivity from the claustrum to the cortex has been studied intensively, the physiological effect and underlying circuit mechanisms of claustrocortical communication remain elusive. Here we show that the claustrum provides strong, widespread, and long-lasting feedforward inhibition of the prefrontal cortex (PFC) sufficient to silence ongoing neural activity. This claustrocortical feedforward inhibition was predominantly mediated by interneurons containing neuropeptide Y, and to a lesser extent those containing parvalbumin. Therefore, in contrast to other long-range excitatory inputs to the PFC, the claustrocortical pathway is designed to provide overall inhibition of cortical activity. This unique circuit organization allows the claustrum to rapidly and powerfully suppress cortical networks and suggests a distinct role for the claustrum in regulating cognitive processes in prefrontal circuits.
NPYPVVIPclaustrumfeed-forward inhibitionmicrocircuitneocortexneurogliaform cellprefrontalsomatostatin interneuronAnimalsBasal GangliaFemaleMaleMiceMice, Inbred C57BLMice, TransgenicNeural InhibitionNeural PathwaysOrgan Culture TechniquesPrefrontal CortexRatsRats, Long-EvansBurdakov FC0010551109 Neurosciences1702 Cognitive Sciences1701 PsychologyNeurology & Neurosurgery