Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.

Downs, Louise O; Okanda, Dorcas; Chirro, Oscar; Zaharani, Mwanakombo; Safari, Benson; Aliyan, Nadia; Andersson, Monique I; Tanaka, Yasuhito; Etyang, Anthony O; Shimakawa, Yusuke; Githinji, George; Matthews, Philippa C

doi:10.25418/crick.28652060.v1

Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.

journal contribution

posted on 2025-03-24, 14:29 authored by Louise O Downs, Dorcas Okanda, Oscar Chirro, Mwanakombo Zaharani, Benson Safari, Nadia Aliyan, Monique I Andersson, Yasuhito Tanaka, Anthony O Etyang, Yusuke Shimakawa, George Githinji, Philippa C Matthews

We undertook a point-of-care test for hepatitis B core-related antigen in adults with hepatitis B virus in Kilifi, Kenya. A positive test identified all individuals with a hepatitis B viral load >200 000 IU/mL and who were hepatitis B e antigen positive. It also correlated with a higher alanine aminotransferase (ALT) level (P = .03), raised aspartate transaminase-to-platelet ratio index (APRI) (P < .001), and higher elastography scores (P = .03).