HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
journal contributionposted on 2021-08-19, 10:19 authored by Rachel PJ Lai, Graeme Meintjes, Robert J Wilkinson
Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.
Drug therapy-complicationsHIV-1 infectionImmune reconstitution inflammatory syndromeTuberculosisAnimalsCoinfectionDisease ManagementDisease Models, AnimalHIV InfectionsHIV-1Host-Pathogen InteractionsHumansImmune Reconstitution Inflammatory SyndromeImmune SystemMycobacterium tuberculosisRisk FactorsSignal TransductionWilkinson, R U117588499Immunology1103 Clinical Sciences