The Francis Crick Institute
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Getting to the heart of an unusual kinetochore

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journal contribution
posted on 2021-08-18, 13:32 authored by Martin R Singleton
The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adaptations found in the Drosophila kinetochore.