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Friction forces position the neural anlage
journal contributionposted on 2020-10-20, 11:04 authored by Michael Smutny, Zsuzsa Ákos, Silvia Grigolon, Shayan Shamipour, Verena Ruprecht, Daniel Čapek, Martin Behrndt, Ekaterina Papusheva, Masazumi Tada, Björn Hof, Tamás Vicsek, Guillaume Salbreux, Carl-Philipp Heisenberg
During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage. Using a combination of experiments and simulations, we show that this process depends on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated adhesion between those tissues. Our data thus establish the emergence of friction forces at the interface between moving tissues as a critical force-generating process shaping the embryo.
AnimalsBiomechanical PhenomenaCadherinsCell CommunicationCell MovementEmbryo, NonmammalianEndodermFrictionGastrulationHydrodynamicsMesodermModels, BiologicalMorphogenesisMutationNervous SystemNeural PlateZebrafishZebrafish ProteinsSalbreux FC001317Developmental Biology06 Biological Sciences11 Medical and Health Sciences