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Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.

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posted on 2024-10-14, 13:39 authored by Jasper Panten, Stefania Del Prete, James P Cleland, Lauren M Saunders, Job van Riet, Anja Schneider, Paul Ginno, Nina Schneider, Marie-Luise Koch, Xuqi Chen, Moritz Gerstung, Oliver Stegle, Arthur P Arnold, James MA Turner, Edith Heard, Duncan T Odom
The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.

Funding

Crick (Grant ID: CC2052, Grant title: Turner CC2052)

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