Genes Dev.-2021-Frost-619-34.pdf (12.71 MB)

Establishing and maintaining fertility: the importance of cell cycle arrest.

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journal contribution
posted on 11.05.2021, 13:50 by Emily R Frost, Güneş Taylor, Mark A Baker, Robin Lovell-Badge, Jessie M Sutherland
Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells and somatic cells proliferate extensively, a process facilitated by cell cycle regulation. This review focuses on the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) in mouse gonad development. We particularly highlight recent single-cell RNA sequencing studies that show the heterogeneity of cyclin-dependent kinase inhibitors. This diversity highlights new roles for cell cycle inhibitors in controlling and maintaining female fertility.

Funding

Crick (Grant ID: 10107, Grant title: Lovell-Badge FC001107) Biotechnology and Biological Sciences Research Council (Grant ID: BB/N018680/1, Grant title: BBSRC BB/N018680/1)

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