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Discovery of lipid-mediated protein–protein interactions in living cells using metabolic labeling with photoactivatable clickable probes

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posted on 2023-03-09, 14:21 authored by Roman O Fedoryshchak, Andrii Gorelik, Mengjie Shen, Maria M Shchepinova, Inmaculada Pérez-Dorado, Edward W Tate
Metabolic labelling of a specific post-translational modification in cells with a bifunctional probe enables site-specific photocrosslinking, enrichment and identification of PTM-mediated protein–protein interactions through quantitative proteomics.

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Crick (Grant ID: 10190, Grant title: Treisman FC001190)

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