The Francis Crick Institute
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Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants.

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journal contribution
posted on 2023-05-30, 08:31 authored by Thao T Le, Donald J Benton, Antoni G Wrobel, Steven J Gamblin
We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed aptamers which can recognise all variants, from the original wild-type 'Wuhan' strain to Omicron, with high affinity (Kd values in the pM range).


Crick (Grant ID: CC2060, Grant title: Gamblin CC2060) Crick (Grant ID: CC1068, Grant title: STP Structural Biology)