The Francis Crick Institute
[14761645 - The American Journal of Tropical Medicine and Hygiene] Determinants of Malaria Protective Immunity in Mice Immunized with Live Sporozoites during Trimethoprim–Sulfamethoxazole Prophylaxis.pdf (514.11 kB)
Download file

Determinants of malaria protective immunity in mice immunized with live sporozoites during trimethoprim-sulfamethoxazole prophylaxis.

Download (514.11 kB)
journal contribution
posted on 2021-02-09, 11:43 authored by Charlotte V Hobbs, Tejram Sahu, Jillian Neal, Solomon Conteh, Tatiana Voza, William Borkowsky, Jean Langhorne, Patrick E Duffy
HIV and malaria geographically overlap. Trimethoprim-sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of antimalarial impact and effect on development of malaria-specific immunity is therefore essential. Using rodent malaria models, we previously showed that repeated Plasmodium exposure during TMP-SMX administration, or chemoprophylaxis vaccination (CVac), induces CD8 T-cell-dependent preerythrocytic immunity. However, humoral immune responses have been shown to be important in models of preerythrocytic immunity. Herein, we demonstrate that antibody-mediated responses contribute to protective immunity induced by CVac immune sera using TMP-SMX in models of homologous, but not heterologous, parasite species. Clinical studies must account for potential anti-Plasmodium antibody induced during TMP-SMX prophylaxis.


Crick (Grant ID: 10101, Grant title: Langhorne FC001101) Wellcome Trust (Grant ID: 104777/Z/14/Z, Grant title: WT 104777/Z/14/Z)


Usage metrics

    The Francis Crick Institute