[14761645 - The American Journal of Tropical Medicine and Hygiene] Determinants of Malaria Protective Immunity in Mice Immunized with Live Sporozoites during Trimethoprim–Sulfamethoxazole Prophylaxis.pdf (514.11 kB)

Determinants of malaria protective immunity in mice immunized with live sporozoites during trimethoprim-sulfamethoxazole prophylaxis.

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posted on 09.02.2021, 11:43 by Charlotte V Hobbs, Tejram Sahu, Jillian Neal, Solomon Conteh, Tatiana Voza, William Borkowsky, Jean Langhorne, Patrick E Duffy
HIV and malaria geographically overlap. Trimethoprim-sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of antimalarial impact and effect on development of malaria-specific immunity is therefore essential. Using rodent malaria models, we previously showed that repeated Plasmodium exposure during TMP-SMX administration, or chemoprophylaxis vaccination (CVac), induces CD8 T-cell-dependent preerythrocytic immunity. However, humoral immune responses have been shown to be important in models of preerythrocytic immunity. Herein, we demonstrate that antibody-mediated responses contribute to protective immunity induced by CVac immune sera using TMP-SMX in models of homologous, but not heterologous, parasite species. Clinical studies must account for potential anti-Plasmodium antibody induced during TMP-SMX prophylaxis.

Funding

Crick (Grant ID: 10101, Grant title: Langhorne FC001101) Wellcome Trust (Grant ID: 104777/Z/14/Z, Grant title: WT 104777/Z/14/Z)

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