annurev-biochem-071322-020214 (1).pdf (4.21 MB)
DNA fragility and repair: some personal recollections
journal contributionposted on 2023-06-22, 13:18 authored by Tomas Robert Lindahl
In this autobiographical article, I reflect on my Swedish background. Then I discuss endogenous DNA alterations and the base excision repair pathway and alternative repair strategies for some unusual DNA lesions. Endogenous DNA damage, such as loss of purine bases and cytosine deamination, is proposed as a major source of cancer-causing mutations.