Cytoskeletal exposure in the regulation of immunity and initiation of tissue repair.
journal contributionposted on 11.11.2020, 13:00 authored by Oliver Gordon, Caetano Reis e Sousa
This article reviews and discusses emerging evidence suggesting an evolutionarily-conserved connection between injury-associated exposure of cytoskeletal proteins and the induction of tolerance to infection, repair of tissue damage and restoration of homeostasis. While differences exist between vertebrates and invertebrates with respect to the receptor(s), cell types, and effector mechanisms involved, the response to exposed cytoskeletal proteins appears to be protective and to rely on a conserved signaling cassette involving Src family kinases, the nonreceptor tyrosine kinase Syk, and tyrosine phosphatases. A case is made for research programs that integrate different model organisms in order to increase the understanding of this putative response to tissue damage.
Crick (Grant ID: 10136, Grant title: Reis e Sousa FC001136) Wellcome Trust (Grant ID: 106973/Z/15/Z, Grant title: WT 106973/Z/15/Z)
DNGR-1actindamage-associated molecular patterns (DAMPs)innate immunitytissue repairα-actininAnimalsCytoskeletal ProteinsCytoskeletonDrosophila melanogasterHumansProtein Tyrosine PhosphatasesRegenerationSignal TransductionSyk KinaseWounds and Injuriessrc-Family KinasesReis e Sousa FC001136Developmental Biology06 Biological Sciences11 Medical and Health Sciences17 Psychology and Cognitive Sciences