The Francis Crick Institute
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Cross-species comparisons and in vitro models to study tempo in development and homeostasis

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journal contribution
posted on 2021-05-26, 08:15 authored by Teresa Rayon, James Briscoe
Time is inherent to biological processes. It determines the order of events and the speed at which they take place. However, we still need to refine approaches to measure the course of time in biological systems and understand what controls the pace of development. Here, we argue that the comparison of biological processes across species provides molecular insight into the timekeeping mechanisms in biology. We discuss recent findings and the open questions in the field and highlight the use of in vitro systems as tools to investigate cell-autonomous control as well as the coordination of temporal mechanisms within tissues. Further, we discuss the relevance of studying tempo for tissue transplantation, homeostasis and lifespan.


Crick (Grant ID: 10051, Grant title: Briscoe FC001051) European Molecular Biology Organization (Grant ID: ALTF 328-2015, Grant title: EMBO ALTF 328-2015) Wellcome Trust (Grant ID: 215116/Z/18/Z, Grant title: WT 215116/Z/18/Z)