1-s2.0-S0304419X17302226-main.pdf (1.25 MB)
Control of metabolism by p53 - cancer and beyond
journal contribution
posted on 2021-05-28, 11:49 authored by Christiaan F Labuschagne, Fabio Zani, Karen H Vousdenp53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, including aging, obesity and diabetes.