Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ-glucose positron emission and computed tomography
journal contributionposted on 2020-07-27, 10:47 authored by Hanif Esmail, Rachel P Lai, Maia Lesosky, Katalin A Wilkinson, Christine M Graham, Anna K Coussens, Tolu Oni, James M Warwick, Qonita Said-Hartley, Coenraad F Koegelenberg, Gerhard Walzl, JoAnne L Flynn, Douglas B Young, Clifton E Barry III, Anne O'Garra, Robert J Wilkinson
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
AdultCoinfectionDisease ProgressionFemaleFluorodeoxyglucose F18HIV InfectionsHumansInterferon-gamma Release TestsLatent TuberculosisMaleMycobacterium tuberculosisPositron Emission Tomography Computed TomographyRadiography, ThoracicRadiopharmaceuticalsSouth AfricaSputumTuberculosisTuberculosis, PulmonaryO'Garra FC001126Wilkinson, R FC001218Young FC00122211 Medical and Health SciencesImmunology