Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice
journal contributionposted on 01.07.2020, 11:50 by Teemu Aitta-aho, Elpiniki Pappa, Denis Burdakov, John Apergis-Schoute
The hypothalamic hypocretin/orexin (HO) system holds a central role in the regulation of several physiological functions critical for food-seeking behavior including mnemonic processes for effective foraging behavior. It is unclear however whether physiological increases in HO neuronal activity can support such processes. Using a designer rM3Ds receptor activation approach increasing HO neuronal activity resulted in improved short-term memory for novel locations. When tested on a non-spatial novelty object recognition task no significant difference was detected between groups indicating that hypothalamic HO neuronal activation can selectively facilitate short-term spatial memory for potentially supporting memory for locations during active exploration.
HypothalamusOrexinRecognition memorySpontaneous alternationAnimalsBehavior, AnimalFemaleMaleMemory, Short-TermMiceMice, Inbred C57BLNeuronsOrexinsRecognition, PsychologySpatial MemoryRecognition (Psychology)Burdakov FC00105511 Medical and Health Sciences17 Psychology and Cognitive SciencesBehavioral Science & Comparative Psychology