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Yeast - 2024 - Albihlal - Budding yeast as an ideal model for elucidating the role of N6‐methyladenosine in regulating gene (1).pdf (1.43 MB)

Budding yeast as an ideal model for elucidating the role of N6 -methyladenosine in regulating gene expression.

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journal contribution
posted on 2024-04-11, 10:11 authored by Waleed S Albihlal, Wei Yee Chan, Folkert J van Werven
N6 -methyladenosine (m6A) is a highly abundant and evolutionarily conserved messenger RNA (mRNA) modification. This modification is installed on RRACH motifs on mRNAs by a hetero-multimeric holoenzyme known as m6A methyltransferase complex (MTC). The m6A mark is then recognised by a group of conserved proteins known as the YTH domain family proteins which guide the mRNA for subsequent downstream processes that determine its fate. In yeast, m6A is installed on thousands of mRNAs during early meiosis by a conserved MTC and the m6A-modified mRNAs are read by the YTH domain-containing protein Mrb1/Pho92. In this review, we aim to delve into the recent advances in our understanding of the regulation and roles of m6A in yeast meiosis. We will discuss the potential functions of m6A in mRNA translation and decay, unravelling their significance in regulating gene expression. We propose that yeast serves as an exceptional model organism for the study of fundamental molecular mechanisms related to the function and regulation of m6A-modified mRNAs. The insights gained from yeast research not only expand our knowledge of mRNA modifications and their molecular roles but also offer valuable insights into the broader landscape of eukaryotic posttranscriptional regulation of gene expression.

Funding

Crick (Grant ID: CC2043, Grant title: van Werven CC2043)

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