s41467-020-19146-5.pdf (909.07 kB)
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
journal contributionposted on 2020-10-26, 09:30 authored by Antoni G Wrobel, Donald J Benton, Saira Hussain, Ruth Harvey, Stephen R Martin, Chloë Roustan, Peter B Rosenthal, John J Skehel, Steven J Gamblin
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.