Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.

Wrobel, Antoni G; Benton, Donald J; Hussain, Saira; Harvey, Ruth; Martin, Stephen R; Roustan, Chloë; Rosenthal, Peter B; Skehel, John J; Gamblin, Steven J

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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.

journal contribution

posted on 2020-10-26, 09:30 authored by Antoni G Wrobel, Donald J Benton, Saira Hussain, Ruth Harvey, Stephen R Martin, Chloë Roustan, Peter B Rosenthal, John J Skehel, Steven J Gamblin

The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.