The Francis Crick Institute
Annotation matters validating the discovery of cancer drivers.pdf (1 MB)
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Annotation matters: validating the discovery of cancer drivers

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journal contribution
posted on 2020-11-12, 11:24 authored by Marta Rodríguez-Martínez, Jesper Q Svejstrup
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of STK19 (Serine Threonine Kinase 19), a previously identified melanoma driver, is a clear example of the importance of such detailed analysis, with both STK19 gene and protein annotations in frequently used databases having been proven incorrect.


Crick (Grant ID: 10166, Grant title: Svejstrup FC001166) European Research Council (Grant ID: 693327 - TRANSDAM, Grant title: ERC 693327 - TRANSDAM)