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Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease.
journal contributionposted on 2023-07-20, 12:40 authored by Marisol Sampedro-Castañeda, Sila K Ultanir
A recent study by Beeman et al. exploring disease-related missense mutations in TAOK1 revealed a self-regulating association of the kinase with the plasma membrane that is critical for neuronal morphogenesis. Using a combination of in vitro approaches and elegant in silico modeling, the authors describe an aberrant membrane protrusions phenotype in kinase-deficient mutants reminiscent of TAOK2's indirect regulation of neuronal morphology, thus providing a converging patho-mechanism across several neurodevelopmental disorders.