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A role for MCH neuron firing in modulating hippocampal plasticity threshold
journal contribution
posted on 2024-01-10, 11:37 authored by Julia J Harris, Denis BurdakovIt has been revealed that hypothalamic neurons containing the peptide, melanin-concentrating hormone (MCH) can influence learning [1] and memory formation [2], but the cellular mechanisms by which they perform this function are not well understood. Here, we examine the role of MCH neural input to the hippocampus, and show in vitro that optogenetically increasing MCH axon activity facilitates hippocampal plasticity by lowering the threshold for synaptic potentiation. These results align with increasing evidence that MCH neurons play a regulatory role in learning, and reveal that this could be achieved by modulating plasticity thresholds in the hippocampus.
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Crick (Grant ID: 10055, Grant title: Burdakov FC001055)
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HippocampusMCHMelanin-concentrating hormoneOptogeneticsSynaptic plasticityBurdakov FC001055Schaefer CC20360304 Medicinal and Biomolecular Chemistry0606 Physiology1115 Pharmacology and Pharmaceutical SciencesEndocrinology & Metabolism3101 Biochemistry and cell biology3202 Clinical sciences3404 Medicinal and biomolecular chemistry
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