The Francis Crick Institute
maizels-2024-a-dynamical-perspective-moving-towards-mechanism-in-single-cell-transcriptomics.pdf (783.33 kB)

A dynamical perspective: moving towards mechanism in single-cell transcriptomics.

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journal contribution
posted on 2024-03-11, 11:25 authored by Rory J Maizels
As the field of single-cell transcriptomics matures, research is shifting focus from phenomenological descriptions of cellular phenotypes to a mechanistic understanding of the gene regulation underneath. This perspective considers the value of capturing dynamical information at single-cell resolution for gaining mechanistic insight; reviews the available technologies for recording and inferring temporal information in single cells; and explores whether better dynamical resolution is sufficient to adequately capture the causal relationships driving complex biological systems. This article is part of a discussion meeting issue 'Causes and consequences of stochastic processes in development and disease'.


Crick (Grant ID: CC2032, Grant title: Briscoe CC2032)